A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants.

A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants.

Variants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the evolution and in vivo fitness of variants in subjects dosed with monotherapy of an HCV protease inhibitor, telaprevir. Variant fitness was est...

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Bibliographic Details
Main Authors: Bambang S Adiwijaya, Eva Herrmann, Brian Hare, Tara Kieffer, Chao Lin, Ann D Kwong, Varun Garg, John C R Randle, Christoph Sarrazin, Stefan Zeuzem, Paul R Caron
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2855330?pdf=render

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http://europepmc.org/articles/PMC2855330?pdf=render

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