Epigenetic Reelin Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders

Epigenetic Reelin Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders

REELN (RELN) is a large (420 kDa) glycoprotein that in adulthood is mostly synthesized in GABAergic neurons of corticolimbic structures. Upon secretion in the extracellular matrix, RELN binds to VLDL, APOE2, and 32 Integrin receptors located on dendritic shafts and spines of postsynaptic pyramidal...

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Bibliographic Details
Main Authors: Alessandro eGuidotti, Dennis R Grayson, Hector M Caruncho
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Bipolar Disorder
Schizophrenia
synaptic plasticity
reelin
promoter methylation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00089/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00089/full

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