Stimulating myocardial regeneration with periostin Peptide in large mammals improves function post-myocardial infarction but increases myocardial fibrosis.

Stimulating myocardial regeneration with periostin Peptide in large mammals improves function post-myocardial infarction but increases myocardial fibrosis.

AIMS: Mammalian myocardium has a finite but limited capacity to regenerate. Experimentally stimulating proliferation of cardiomyocytes with extracellular regeneration factors like periostin enhances cardiac repair in rodents. The aim of this study was to develop a safe method for delivering regenera...

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Bibliographic Details
Main Authors: Dennis Ladage, Elisa Yaniz-Galende, Kleopatra Rapti, Kiyotake Ishikawa, Lisa Tilemann, Scott Shapiro, Yoshiaki Takewa, Jochen Muller-Ehmsen, Martin Schwarz, Mario J Garcia, Javier Sanz, Roger J Hajjar, Yoshiaki Kawase
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3659021?pdf=render

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http://europepmc.org/articles/PMC3659021?pdf=render

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