Recruitment of 53BP1 Proteins for DNA Repair and Persistence of Repair Clusters Differ for Cell Types as Detected by Single Molecule Localization Microscopy

Recruitment of 53BP1 Proteins for DNA Repair and Persistence of Repair Clusters Differ for Cell Types as Detected by Single Molecule Localization Microscopy

DNA double stranded breaks (DSBs) are the most serious type of lesions introduced into chromatin by ionizing radiation. During DSB repair, cells recruit different proteins to the damaged sites in a manner dependent on local chromatin structure, DSB location in the nucleus, and the repair pathway ent...

Full description

Bibliographic Details
Main Authors: Elizaveta Bobkova, Daniel Depes, Jin-Ho Lee, Lucie Jezkova, Iva Falkova, Eva Pagacova, Olga Kopecna, Mariia Zadneprianetc, Alena Bacikova, Elena Kulikova, Elena Smirnova, Tatiana Bulanova, Alla Boreyko, Evgeny Krasavin, Frederik Wenz, Felix Bestvater, Georg Hildenbrand, Michael Hausmann, Martin Falk
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
repair foci nano-architecture
<sup>15</sup>N ion irradiation
single molecule localization microscopy (SMLM)
repair cluster formation
repair cluster persistence
Online Access:https://www.mdpi.com/1422-0067/19/12/3713

Internet

https://www.mdpi.com/1422-0067/19/12/3713

Similar Items