Quantifying the Genetic Basis of Marfan Syndrome Clinical Variability

Quantifying the Genetic Basis of Marfan Syndrome Clinical Variability

Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder with considerable inter- and intra-familial clinical variability. The contribution of inherited modifiers to variability has not been quantified. We analyzed the distribution of 23 clinical features in 1306 well-phenotyped MFS...

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Bibliographic Details
Main Authors: Thomas Grange, Mélodie Aubart, Maud Langeois, Louise Benarroch, Pauline Arnaud, Olivier Milleron, Ludivine Eliahou, Marie-Sylvie Gross, Nadine Hanna, Catherine Boileau, Laurent Gouya, Guillaume Jondeau
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Genes
Subjects:
marfan
heritability
modifiers
fibrillin
Online Access:https://www.mdpi.com/2073-4425/11/5/574

Internet

https://www.mdpi.com/2073-4425/11/5/574

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