An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans.

An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans.

Purpura fulminans is a deadly complication of Neisseria meningitidis infections due to extensive thrombosis of microvessels. Although a Disseminated Intra-vascular Coagulation syndrome (DIC) is frequently observed during Gram negative sepsis, it is rarely associated with extensive thrombosis like th...

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Bibliographic Details
Main Authors: Hervé Lécuyer, Zoé Virion, Jean-Philippe Barnier, Soraya Matczak, Sandrine Bourdoulous, Elsa Bianchini, François Saller, Delphine Borgel, Xavier Nassif, Mathieu Coureuil
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1006981

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https://doi.org/10.1371/journal.ppat.1006981

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