Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

Abstract Mutant Cu/Zn superoxide dismutase (SOD1) causes mitochondrial alterations that contribute to motor neuron demise in amyotrophic lateral sclerosis (ALS). When mitochondria are damaged, cells activate mitochondria quality control (MQC) mechanisms leading to mitophagy. Here, we show that in th...

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Bibliographic Details
Main Authors: Gloria M Palomo, Veronica Granatiero, Hibiki Kawamata, Csaba Konrad, Michelle Kim, Andrea J Arreguin, Dazhi Zhao, Teresa A Milner, Giovanni Manfredi
Format: Article
Language:English
Published: Wiley 2018-10-01
Series:EMBO Molecular Medicine
Subjects:
amyotrophic lateral sclerosis
mitochondria quality control
mitophagy
Parkin
SOD1
Online Access:https://doi.org/10.15252/emmm.201808888

Internet

https://doi.org/10.15252/emmm.201808888

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