Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1

Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1

Background and Aims: Tongxinluo (TXL) is a multifunctional traditional Chinese medicine that has been widely used to treat cardiovascular and cerebrovascular diseases. However, no studies have explored whether TXL can protect human cardiomyocytes (HCMs) from ischemia/reperfusion (I/R) injury. Reperf...

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Bibliographic Details
Main Authors: Gui-hao Chen, Chuan-sheng Xu, Jie Zhang, Qing Li, He-he Cui, Xiang-dong Li, Li-ping Chang, Rui-jie Tang, Jun-yan Xu, Xia-qiu Tian, Pei-sen Huang, Jun Xu, Chen Jin, Yue-jin Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Pharmacology
Subjects:
myocardial reperfusion injury
cardioprotection
tongxinluo
human cardiomyocytes
apoptosis
p70s6k1
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00775/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00775/full

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