Awakening the HSC: Dynamic Modeling of HSC Maintenance Unravels Regulation of the TP53 Pathway and Quiescence

Awakening the HSC: Dynamic Modeling of HSC Maintenance Unravels Regulation of the TP53 Pathway and Quiescence

Hematopoietic stem cells (HSCs) provide all types of blood cells during the entire life of the organism. HSCs are mainly quiescent and can eventually enter the cell cycle to differentiate. HSCs are maintained and tightly regulated in a particular environment. The stem cell niche regulates dormancy a...

Full description

Bibliographic Details
Main Authors: Nensi Ikonomi, Silke D. Kühlwein, Julian D. Schwab, Hans A. Kestler
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Physiology
Subjects:
hematopoietic stem cell
Boolean network
dynamic modeling
TP53
stem cell awakening
maintenance of quiescence
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00848/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00848/full

Similar Items