Piplartine Analogues and Cytotoxic Evaluation against Glioblastoma

Piplartine Analogues and Cytotoxic Evaluation against Glioblastoma

Piplartine (1) is an alkamide extracted from plants of the genus Piper which shows several pharmacological properties, including antitumor activity. To improve this activity, a series of analogues based on 1 have been synthesized by esterification and amidation using the 3,4,5-trimethoxycinnamic aci...

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Bibliographic Details
Main Authors: Flávio Rogério da Nóbrega, Ozlem Ozdemir, Sheila Cristina S. Nascimento Sousa, Joice Nascimento Barboza, Hasan Turkez, Damião Pergentino de Sousa
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
cancer
cytotoxic activity
antitumor
phenylpropanoid
alkaloid
natural product
esters
oxidative stress
Piper
synthetic derivatives
Online Access:http://www.mdpi.com/1420-3049/23/6/1382

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http://www.mdpi.com/1420-3049/23/6/1382

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