Serine protease HTRA1 antagonizes transforming growth factor-β signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation.

Serine protease HTRA1 antagonizes transforming growth factor-β signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation.

HTRA1 is a member of the High Temperature Requirement (HTRA1) family of serine proteases, which play a role in several biological and pathological processes. In part, HTRA1 regulation occurs by inhibiting the TGF-β signaling pathway, however the mechanism of inhibition has not been fully defined. Pr...

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Bibliographic Details
Main Authors: Julie R Graham, Angela Chamberland, Qingcong Lin, X Jian Li, David Dai, Weilan Zeng, Mark S Ryan, Moisés A Rivera-Bermúdez, Carl R Flannery, Zhiyong Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3770692?pdf=render

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http://europepmc.org/articles/PMC3770692?pdf=render

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