Skewness of X-chromosome inactivation increases with age and varies across birth cohorts in elderly Danish women

Abstract Mosaicism in blood varies with age, and cross-sectional studies indicate that for women, skewness of X-chromosomal mosaicism increases with age. This pattern could, however, also be due to less X-inactivation in more recent birth cohorts. Skewed X-chromosome inactivation was here measured l...

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Bibliographic Details
Main Authors: Jonas Mengel-From, Rune Lindahl-Jacobsen, Marianne Nygaard, Mette Soerensen, Karen Helene Ørstavik, Jens Michael Hertz, Karen Andersen-Ranberg, Qihua Tan, Kaare Christensen
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83702-2