Germline contamination and leakage in whole genome somatic single nucleotide variant detection

Germline contamination and leakage in whole genome somatic single nucleotide variant detection

Abstract Background The clinical sequencing of cancer genomes to personalize therapy is becoming routine across the world. However, concerns over patient re-identification from these data lead to questions about how tightly access should be controlled. It is not thought to be possible to re-identify...

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Bibliographic Details
Main Authors: Dorota H. Sendorek, Cristian Caloian, Kyle Ellrott, J. Christopher Bare, Takafumi N. Yamaguchi, Adam D. Ewing, Kathleen E. Houlahan, Thea C. Norman, Adam A. Margolin, Joshua M. Stuart, Paul C. Boutros
Format: Article
Language:English
Published: BMC 2018-01-01
Series:BMC Bioinformatics
Subjects:
Cancer genomics
Next-generation sequencing
Mutation calling
Germline contamination
Germline leakage
Patient identifiability
Online Access:http://link.springer.com/article/10.1186/s12859-018-2046-0

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http://link.springer.com/article/10.1186/s12859-018-2046-0

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