Evolution of RNA-protein interactions: non-specific binding led to RNA splicing activity of fungal mitochondrial tyrosyl-tRNA synthetases.

Evolution of RNA-protein interactions: non-specific binding led to RNA splicing activity of fungal mitochondrial tyrosyl-tRNA synthetases.

The Neurospora crassa mitochondrial tyrosyl-tRNA synthetase (mtTyrRS; CYT-18 protein) evolved a new function as a group I intron splicing factor by acquiring the ability to bind group I intron RNAs and stabilize their catalytically active RNA structure. Previous studies showed: (i) CYT-18 binds grou...

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Bibliographic Details
Main Authors: Lilian T Lamech, Anna L Mallam, Alan M Lambowitz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-12-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4275181?pdf=render

Internet

http://europepmc.org/articles/PMC4275181?pdf=render

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