TGF-β1 Downregulates the Expression of CX3CR1 by Inducing miR-27a-5p in Primary Human NK Cells

TGF-β1 Downregulates the Expression of CX3CR1 by Inducing miR-27a-5p in Primary Human NK Cells

Activity of human natural killer (NK) cells against cancer cells is deeply suppressed by TGF-β1, an immunomodulatory cytokine that is released and activated in the tumor microenvironment. Moreover, our previous data showed that TGF-β1 modifies the chemokine receptor repertoire of NK cells. In partic...

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Bibliographic Details
Main Authors: Stefano Regis, Fabio Caliendo, Alessandra Dondero, Beatrice Casu, Filomena Romano, Fabrizio Loiacono, Alessandro Moretta, Cristina Bottino, Roberta Castriconi
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Immunology
Subjects:
TGF-β1
chemokine receptors
microRNAs
NK cells
tumor microenvironment
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00868/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00868/full

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