Local penetration of doxorubicin via intrahepatic implantation of PLGA based doxorubicin-loaded implants

Local penetration of doxorubicin via intrahepatic implantation of PLGA based doxorubicin-loaded implants

Doxorubicin (DOX) is widely used in the chemotherapy of a wide range of cancers. However, intravenous administration of DOX causes toxicity to most major organs which limits its clinical application. DOX-loaded drug delivery system could provide a continuous sustained-release of drugs and enables hi...

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Bibliographic Details
Main Authors: Li Gao, Qingshan Li, Jie Zhang, Yixin Huang, Lin Deng, Chenyang Li, Guangping Tai, Banfeng Ruan
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Drug Delivery
Subjects:
doxorubicin
implants
uplc-ms/ms
minipig
local penetration
Online Access:http://dx.doi.org/10.1080/10717544.2019.1676842

Internet

http://dx.doi.org/10.1080/10717544.2019.1676842

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