Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin prevents cancer progression. How metformin diminishes tumor growth is not fully understood. In this study, we report that in human cancer cells, metformin inhibits mitochondrial complex I (NADH dehydrog...

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Bibliographic Details
Main Authors: William W Wheaton, Samuel E Weinberg, Robert B Hamanaka, Saul Soberanes, Lucas B Sullivan, Elena Anso, Andrea Glasauer, Eric Dufour, Gokhan M Mutlu, GR Scott Budigner, Navdeep S Chandel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-05-01
Series:eLife
Subjects:
metformin
cancer
mitochondria
Online Access:https://elifesciences.org/articles/02242

Internet

https://elifesciences.org/articles/02242

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