Integrative Analysis of DNA Methylation and microRNA Expression Reveals Mechanisms of Racial Heterogeneity in Hepatocellular Carcinoma

Integrative Analysis of DNA Methylation and microRNA Expression Reveals Mechanisms of Racial Heterogeneity in Hepatocellular Carcinoma

Pathologic alterations in epigenetic regulation have long been considered a hallmark of many cancers, including hepatocellular carcinoma (HCC). In a healthy individual, the relationship between DNA methylation and microRNA (miRNA) expression maintains a fine balance; however, disruptions in this har...

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Bibliographic Details
Main Authors: Rency S. Varghese, Megan E. Barefoot, Sidharth Jain, Yifan Chen, Yunxi Zhang, Amber Alley, Alexander H. Kroemer, Mahlet G. Tadesse, Deepak Kumar, Zaki A. Sherif, Habtom W. Ressom
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Genetics
Subjects:
epigenomic and transcriptomic data
DNA methylation
miRNA expression
cancer disparities
hepatocellular carcinoma
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.708326/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.708326/full

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