The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis

The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis

The deubiquitylase OTUD3 can function as a tumour-suppressor by stabilizing PTEN. Here, the authors show that OTUD3 also has an oncogenic role in lung cancer by stabilizing the glucose-regulated protein GRP78.

Bibliographic Details
Main Authors: Tongde Du, Hongchang Li, Yongsheng Fan, Lin Yuan, Xiaodan Guo, Qiong Zhu, Yuying Yao, Xin Li, Chunlei Liu, Xinhe Yu, Zhaofei Liu, Chun-Ping Cui, Chuanchun Han, Lingqiang Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10824-7

Internet

https://doi.org/10.1038/s41467-019-10824-7

Similar Items