The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice.

The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice.

Skeletal muscle atrophy is a consequence of muscle inactivity resulting from denervation, unloading and immobility. It accompanies many chronic disease states and also occurs as a pathophysiologic consequence of normal aging. In all these conditions, ubiquitin-dependent proteolysis is a key regulato...

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Bibliographic Details
Main Authors: Preena Nagpal, Pamela J Plant, Judy Correa, Alexandra Bain, Michiko Takeda, Hiroshi Kawabe, Daniela Rotin, James R Bain, Jane A E Batt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3482220?pdf=render

Internet

http://europepmc.org/articles/PMC3482220?pdf=render

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