Time-Dependent, HIV-Tat-Induced Perturbation of Human Neurons In Vitro: Towards a Model for the Molecular Pathology of HIV-Associated Neurocognitive Disorders

Time-Dependent, HIV-Tat-Induced Perturbation of Human Neurons In Vitro: Towards a Model for the Molecular Pathology of HIV-Associated Neurocognitive Disorders

A significant proportion of human immunodeficiency virus type 1 (HIV)-positive individuals are affected by the cognitive, motor and behavioral dysfunction that characterizes HIV-associated neurocognitive disorders (HAND). While the molecular etiology of HAND remains largely uncharacterized, HIV tran...

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Bibliographic Details
Main Authors: Kim T. Gurwitz, Richard J. Burman, Brandon D. Murugan, Shaun Garnett, Tariq Ganief, Nelson C. Soares, Joseph V. Raimondo, Jonathan M. Blackburn
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neuronal cell culture
HIV-Tat
mass spectrometry
proteomics
whole-cell patch clamp
intrinsic neuronal properties
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00163/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00163/full

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