A novel small molecule 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose mimics the antiplatelet actions of insulin.

A novel small molecule 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose mimics the antiplatelet actions of insulin.

BACKGROUND: We have shown that 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose (α-PGG), an orally effective hypoglycemic small molecule, binds to insulin receptors and activates insulin-mediated glucose transport. Insulin has been shown to bind to its receptors on platelets and inhibit platelet activati...

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Bibliographic Details
Main Authors: Rehana Perveen, Kevin Funk, Jean Thuma, Shelli Wulf Ridge, Yanyan Cao, Jan Willem N Akkerman, Xiaozhuo Chen, Huzoor Akbar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3206812?pdf=render

Internet

http://europepmc.org/articles/PMC3206812?pdf=render

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