Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner.

Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner.

BACKGROUND: Bone fracture initiates a series of cellular and molecular events including the expression of hypoxia-inducible factor (HIF)-1. HIF-1 is known to facilitate recruitment and differentiation of multipotent human mesenchymal stromal cells (hMSC). Therefore, we analyzed the impact of hypoxia...

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Main Authors: Markus Wagegg, Timo Gaber, Ferenz L Lohanatha, Martin Hahne, Cindy Strehl, Monique Fangradt, Cam Loan Tran, Kerstin Schönbeck, Paula Hoff, Andrea Ode, Carsten Perka, Georg N Duda, Frank Buttgereit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3459928?pdf=render

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http://europepmc.org/articles/PMC3459928?pdf=render

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