Hypoxia promotes osteogenesis but suppresses adipogenesis of human mesenchymal stromal cells in a hypoxia-inducible factor-1 dependent manner.
BACKGROUND: Bone fracture initiates a series of cellular and molecular events including the expression of hypoxia-inducible factor (HIF)-1. HIF-1 is known to facilitate recruitment and differentiation of multipotent human mesenchymal stromal cells (hMSC). Therefore, we analyzed the impact of hypoxia...
Main Authors: | Markus Wagegg, Timo Gaber, Ferenz L Lohanatha, Martin Hahne, Cindy Strehl, Monique Fangradt, Cam Loan Tran, Kerstin Schönbeck, Paula Hoff, Andrea Ode, Carsten Perka, Georg N Duda, Frank Buttgereit |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3459928?pdf=render |
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