Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice

Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice

Endoplasmic reticulum (ER) stress-induced neuronal death may play a critical role in the pathogenesis of amyotrophic lateral sclerosis (ALS). However, whether CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP), an ER-stress apoptotic mediator, is involved in the pathogenesis of ALS is...

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Bibliographic Details
Main Authors: Yasushi Ito, Mitsunori Yamada, Hirotaka Tanaka, Kazunari Aida, Kazuhiro Tsuruma, Masamitsu Shimazawa, Isao Hozumi, Takashi Inuzuka, Hitoshi Takahashi, Hideaki Hara
Format: Article
Language:English
Published: Elsevier 2009-12-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis (ALS)
Astrocyte
C/EBP homologous protein (CHOP)
Endoplasmic reticulum (ER) stress
Superoxide dismutase 1 (SOD1)
Spinal cord
Online Access:http://www.sciencedirect.com/science/article/pii/S096999610900240X

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http://www.sciencedirect.com/science/article/pii/S096999610900240X

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