Heme Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1

Heme Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1

Atypical hemolytic uremic syndrome (aHUS) is a severe disease characterized by microvascular endothelial cell (EC) lesions leading to thrombi formation, mechanical hemolysis and organ failure, predominantly renal. Complement system overactivation is a hallmark of aHUS. To investigate this selective...

Full description

Bibliographic Details
Main Authors: Olivia May, Nicolas S. Merle, Anne Grunenwald, Viviane Gnemmi, Juliette Leon, Cloé Payet, Tania Robe-Rybkine, Romain Paule, Florian Delguste, Simon C. Satchell, Peter W. Mathieson, Marc Hazzan, Eric Boulanger, Jordan D. Dimitrov, Veronique Fremeaux-Bacchi, Marie Frimat, Lubka T. Roumenina
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
atypical hemolytic uremic syndrome
complement system
endothelial cells
heme
heme oxygenase-1
thrombomodulin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03008/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03008/full

Similar Items