Inhibition of Ca<sup>2+</sup>/Calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in Rats

Inhibition of Ca<sup>2+</sup>/Calmodulin-dependent protein kinase II reverses oxaliplatin-induced mechanical allodynia in Rats

<p>Abstract</p> <p>Background</p> <p>Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes severe peripheral neuropathy. We previously reported that oxaliplatin (4 mg/kg, i.p., twice a week) induces mechanical allodynia in the late phase in rats...

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Bibliographic Details
Main Authors: Shirahama Masafumi, Ushio Soichiro, Egashira Nobuaki, Yamamoto Shota, Sada Hikaru, Masuguchi Ken, Kawashiri Takehiro, Oishi Ryozo
Format: Article
Language:English
Published: SAGE Publishing 2012-04-01
Series:Molecular Pain
Online Access:http://www.molecularpain.com/content/8/1/26

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http://www.molecularpain.com/content/8/1/26

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