Stromal interferon-γ signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice.

Stromal interferon-γ signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice.

To study mechanisms of T cell-mediated rejection of B cell lymphomas, we developed a murine lymphoma model wherein three potential rejection antigens, human c-MYC, chicken ovalbumin (OVA), and GFP are expressed. After transfer into wild-type mice 60-70% of systemically growing lymphomas expressing a...

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Bibliographic Details
Main Authors: Armin Gerbitz, Madhusudhanan Sukumar, Florian Helm, Andrea Wilke, Christian Friese, Cornelia Fahrenwaldt, Frank M Lehmann, Christoph Loddenkemper, Thomas Kammertoens, Josef Mautner, Clemens A Schmitt, Thomas Blankenstein, Georg W Bornkamm
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3316708?pdf=render

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http://europepmc.org/articles/PMC3316708?pdf=render

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