Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing.

Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing.

For over 130 years, invasive pneumococcal disease has been associated with the presence of extracellular planktonic pneumococci, i.e. diplococci or short chains in affected tissues. Herein, we show that Streptococcus pneumoniae that invade the myocardium instead replicate within cellular vesicles an...

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Bibliographic Details
Main Authors: Anukul T Shenoy, Terry Brissac, Ryan P Gilley, Nikhil Kumar, Yong Wang, Norberto Gonzalez-Juarbe, Whitney S Hinkle, Sean C Daugherty, Amol C Shetty, Sandra Ott, Luke J Tallon, Jessy Deshane, Hervé Tettelin, Carlos J Orihuela
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1006582

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https://doi.org/10.1371/journal.ppat.1006582

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