MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides

MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides

It is well-known that heparin and other glycosaminoglycans (GAGs) inhibit complement activation. It is however not known whether fractionation and/or modification of GAGs might deliver pathway-specific inhibition of the complement system. Therefore, we evaluated a library of GAGs and their derivativ...

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Bibliographic Details
Main Authors: Ditmer T. Talsma, Felix Poppelaars, Wendy Dam, Anita H. Meter-Arkema, Romain R. Vivès, Peter Gál, Geert-Jan Boons, Pradeep Chopra, Annamaria Naggi, Marc A. Seelen, Stephan P. Berger, Mohamed R. Daha, Coen A. Stegeman, Jacob van den Born, the COMBAT Consortium
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Immunology
Subjects:
lectin pathway
MASP-2
tetrasaccharide
heparin
complement
glycosaminoglycans
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00732/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.00732/full

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