Regulation of mTORC1 by Upstream Stimuli
The mammalian target of rapamycin (mTOR) is an evolutionary conserved Ser/Thr protein kinase that senses multiple upstream stimuli to control cell growth, metabolism, and autophagy. mTOR is the catalytic subunit of mTOR complex 1 (mTORC1). A significant amount of research has uncovered the signaling...
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MDPI AG
2020-08-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/11/9/989 |
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doaj-ab419d58807241f6abae113c75db571e2020-11-25T03:39:30ZengMDPI AGGenes2073-44252020-08-011198998910.3390/genes11090989Regulation of mTORC1 by Upstream StimuliChase H. Melick0Jenna L. Jewell1Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USADepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USAThe mammalian target of rapamycin (mTOR) is an evolutionary conserved Ser/Thr protein kinase that senses multiple upstream stimuli to control cell growth, metabolism, and autophagy. mTOR is the catalytic subunit of mTOR complex 1 (mTORC1). A significant amount of research has uncovered the signaling pathways regulated by mTORC1, and the involvement of these signaling cascades in human diseases like cancer, diabetes, and ageing. Here, we review advances in mTORC1 regulation by upstream stimuli. We specifically focus on how growth factors, amino acids, G-protein coupled receptors (GPCRs), phosphorylation, and small GTPases regulate mTORC1 activity and signaling.https://www.mdpi.com/2073-4425/11/9/989mTORC1amino acidsG-protein coupled receptorssmall GTPaseskinasesphosphorylation |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Chase H. Melick Jenna L. Jewell |
| spellingShingle |
Chase H. Melick Jenna L. Jewell Regulation of mTORC1 by Upstream Stimuli Genes mTORC1 amino acids G-protein coupled receptors small GTPases kinases phosphorylation |
| author_facet |
Chase H. Melick Jenna L. Jewell |
| author_sort |
Chase H. Melick |
| title |
Regulation of mTORC1 by Upstream Stimuli |
| title_short |
Regulation of mTORC1 by Upstream Stimuli |
| title_full |
Regulation of mTORC1 by Upstream Stimuli |
| title_fullStr |
Regulation of mTORC1 by Upstream Stimuli |
| title_full_unstemmed |
Regulation of mTORC1 by Upstream Stimuli |
| title_sort |
regulation of mtorc1 by upstream stimuli |
| publisher |
MDPI AG |
| series |
Genes |
| issn |
2073-4425 |
| publishDate |
2020-08-01 |
| description |
The mammalian target of rapamycin (mTOR) is an evolutionary conserved Ser/Thr protein kinase that senses multiple upstream stimuli to control cell growth, metabolism, and autophagy. mTOR is the catalytic subunit of mTOR complex 1 (mTORC1). A significant amount of research has uncovered the signaling pathways regulated by mTORC1, and the involvement of these signaling cascades in human diseases like cancer, diabetes, and ageing. Here, we review advances in mTORC1 regulation by upstream stimuli. We specifically focus on how growth factors, amino acids, G-protein coupled receptors (GPCRs), phosphorylation, and small GTPases regulate mTORC1 activity and signaling. |
| topic |
mTORC1 amino acids G-protein coupled receptors small GTPases kinases phosphorylation |
| url |
https://www.mdpi.com/2073-4425/11/9/989 |
| work_keys_str_mv |
AT chasehmelick regulationofmtorc1byupstreamstimuli AT jennaljewell regulationofmtorc1byupstreamstimuli |
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1724538421146288128 |