KMRC011, an agonist of toll-like receptor 5, mitigates irradiation-induced tissue damage and mortality in cynomolgus monkeys

KMRC011, an agonist of toll-like receptor 5, mitigates irradiation-induced tissue damage and mortality in cynomolgus monkeys

In the study here, the potential applicability of KMRC011 - an agonist of toll-like receptor-5 – as a countermeasure for radiation toxicities was evaluated. Following a single 5.5 Gy total body irradiation (TBI, surface absorbed dose = 7 Gy) of Co60 γ-rays, mortality rates and degrees of pathologica...

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Bibliographic Details
Main Authors: Hong-Soo Lee, Doo-Wan Cho, Ji-Seok Han, Su-Cheol Han, Sang Keun Woo, Soo-Youn Jun, Woo-Jong Lee, Susie Yoon, Son-Il Pak, Sang-Jin Lee, Eunsol Seong, Eun-Jung Park
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Immunotoxicology
Subjects:
radiation therapy
medical radiation countermeasure
toll-like receptor 5
entolimod
caveolin-1
Online Access:http://dx.doi.org/10.1080/1547691X.2019.1699617

Internet

http://dx.doi.org/10.1080/1547691X.2019.1699617

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