Exploiting Botulinum Neurotoxins for the Study of Brain Physiology and Pathology

Botulinum neurotoxins are metalloproteases that specifically cleave N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins in synaptic terminals, resulting in a potent inhibition of vesicle fusion and transmitter release. The family comprises different serotypes (BoNT/A to Bo...

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Bibliographic Details
Main Authors: Matteo Caleo, Laura Restani
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Toxins
Subjects:
Online Access:http://www.mdpi.com/2072-6651/10/5/175