Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity
Cytosine base editors have been reported to induce off-target mutations in DNA and RNA. Here the authors identify next-generation CBEs with reduced guide-independent off-target editing profiles and retain high on-target editing activity.
Main Authors: | Yi Yu, Thomas C. Leete, David A. Born, Lauren Young, Luis A. Barrera, Seung-Joo Lee, Holly A. Rees, Giuseppe Ciaramella, Nicole M. Gaudelli |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-04-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-15887-5 |
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