FOXO3 Shares Common Targets with ASCL1 Genome-wide and Inhibits ASCL1-Dependent Neurogenesis

FOXO3 Shares Common Targets with ASCL1 Genome-wide and Inhibits ASCL1-Dependent Neurogenesis

FOXO transcription factors are central regulators of longevity from worms to humans. FOXO3, the FOXO isoform associated with exceptional human longevity, preserves adult neural stem cell pools. Here, we identify FOXO3 direct targets genome-wide in primary cultures of adult neural progenitor cells (...

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Bibliographic Details
Main Authors: Ashley E. Webb, Elizabeth A. Pollina, Thomas Vierbuchen, Noelia Urbán, Duygu Ucar, Dena S. Leeman, Ben Martynoga, Madhavi Sewak, Thomas A. Rando, François Guillemot, Marius Wernig, Anne Brunet
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713003276

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http://www.sciencedirect.com/science/article/pii/S2211124713003276

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