Solasonine Suppresses the Proliferation of Acute Monocytic Leukemia Through the Activation of the AMPK/FOXO3A Axis

Solasonine Suppresses the Proliferation of Acute Monocytic Leukemia Through the Activation of the AMPK/FOXO3A Axis

Solasonine, the main active ingredient of Solanum nigrum L., has been reported to exert extensive antitumor activity. However, the antitumor effects in acute monocytic leukemia and the exact mechanisms involved are unknown. In this study, we investigated the role of solasonine on inhibiting the prog...

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Bibliographic Details
Main Authors: Hong Zhang, Fang Tian, Pengjun Jiang, Shushu Qian, Xingbin Dai, Bangyun Ma, Mengya Wang, Huibo Dai, Xiaocao Sha, Zhongfa Yang, Xuejun Zhu, Xuemei Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
solasonine
Solanum nigrum L.
acute monocytic leukemia
AMPK
FOXO3A
AMPK/FOXO3A
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.614067/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.614067/full

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