GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery

GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery

Expansion of the chemical diversity of glycopeptide antibiotics (GPAs) to deal with the emergence and spread of GPA resistance is challenging. Here, the authors report a GPA synthetic biology platform in Streptomyces coelicolor for Type IV–V glycopeptide antibiotic production and discovery.

Bibliographic Details
Main Authors: Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth J. Culp, Allison K. Guitor, Gerard D. Wright
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19138-5

Internet

https://doi.org/10.1038/s41467-020-19138-5

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