GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery

GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery

Expansion of the chemical diversity of glycopeptide antibiotics (GPAs) to deal with the emergence and spread of GPA resistance is challenging. Here, the authors report a GPA synthetic biology platform in Streptomyces coelicolor for Type IV–V glycopeptide antibiotic production and discovery.

Bibliographic Details
Main Authors: Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth J. Culp, Allison K. Guitor, Gerard D. Wright
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19138-5
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spelling doaj-ab52388badb54b27817cdc937f1fa5d52021-05-11T08:03:34ZengNature Publishing GroupNature Communications2041-17232020-10-0111111210.1038/s41467-020-19138-5GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discoveryMin Xu0Wenliang Wang1Nicholas Waglechner2Elizabeth J. Culp3Allison K. Guitor4Gerard D. Wright5David Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster UniversityDavid Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster UniversityDavid Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster UniversityDavid Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster UniversityDavid Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster UniversityDavid Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster UniversityExpansion of the chemical diversity of glycopeptide antibiotics (GPAs) to deal with the emergence and spread of GPA resistance is challenging. Here, the authors report a GPA synthetic biology platform in Streptomyces coelicolor for Type IV–V glycopeptide antibiotic production and discovery.https://doi.org/10.1038/s41467-020-19138-5
collection DOAJ
language English
format Article
sources DOAJ
author Min Xu
Wenliang Wang
Nicholas Waglechner
Elizabeth J. Culp
Allison K. Guitor
Gerard D. Wright
spellingShingle Min Xu
Wenliang Wang
Nicholas Waglechner
Elizabeth J. Culp
Allison K. Guitor
Gerard D. Wright
GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery
Nature Communications
author_facet Min Xu
Wenliang Wang
Nicholas Waglechner
Elizabeth J. Culp
Allison K. Guitor
Gerard D. Wright
author_sort Min Xu
title GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery
title_short GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery
title_full GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery
title_fullStr GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery
title_full_unstemmed GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery
title_sort gpahex-a synthetic biology platform for type iv–v glycopeptide antibiotic production and discovery
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-10-01
description Expansion of the chemical diversity of glycopeptide antibiotics (GPAs) to deal with the emergence and spread of GPA resistance is challenging. Here, the authors report a GPA synthetic biology platform in Streptomyces coelicolor for Type IV–V glycopeptide antibiotic production and discovery.
url https://doi.org/10.1038/s41467-020-19138-5
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AT wenliangwang gpahexasyntheticbiologyplatformfortypeivvglycopeptideantibioticproductionanddiscovery
AT nicholaswaglechner gpahexasyntheticbiologyplatformfortypeivvglycopeptideantibioticproductionanddiscovery
AT elizabethjculp gpahexasyntheticbiologyplatformfortypeivvglycopeptideantibioticproductionanddiscovery
AT allisonkguitor gpahexasyntheticbiologyplatformfortypeivvglycopeptideantibioticproductionanddiscovery
AT gerarddwright gpahexasyntheticbiologyplatformfortypeivvglycopeptideantibioticproductionanddiscovery
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