GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery
Expansion of the chemical diversity of glycopeptide antibiotics (GPAs) to deal with the emergence and spread of GPA resistance is challenging. Here, the authors report a GPA synthetic biology platform in Streptomyces coelicolor for Type IV–V glycopeptide antibiotic production and discovery.
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-10-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-19138-5 |
id |
doaj-ab52388badb54b27817cdc937f1fa5d5 |
---|---|
record_format |
Article |
spelling |
doaj-ab52388badb54b27817cdc937f1fa5d52021-05-11T08:03:34ZengNature Publishing GroupNature Communications2041-17232020-10-0111111210.1038/s41467-020-19138-5GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discoveryMin Xu0Wenliang Wang1Nicholas Waglechner2Elizabeth J. Culp3Allison K. Guitor4Gerard D. Wright5David Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster UniversityDavid Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster UniversityDavid Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster UniversityDavid Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster UniversityDavid Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster UniversityDavid Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster UniversityExpansion of the chemical diversity of glycopeptide antibiotics (GPAs) to deal with the emergence and spread of GPA resistance is challenging. Here, the authors report a GPA synthetic biology platform in Streptomyces coelicolor for Type IV–V glycopeptide antibiotic production and discovery.https://doi.org/10.1038/s41467-020-19138-5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Min Xu Wenliang Wang Nicholas Waglechner Elizabeth J. Culp Allison K. Guitor Gerard D. Wright |
spellingShingle |
Min Xu Wenliang Wang Nicholas Waglechner Elizabeth J. Culp Allison K. Guitor Gerard D. Wright GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery Nature Communications |
author_facet |
Min Xu Wenliang Wang Nicholas Waglechner Elizabeth J. Culp Allison K. Guitor Gerard D. Wright |
author_sort |
Min Xu |
title |
GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery |
title_short |
GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery |
title_full |
GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery |
title_fullStr |
GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery |
title_full_unstemmed |
GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery |
title_sort |
gpahex-a synthetic biology platform for type iv–v glycopeptide antibiotic production and discovery |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2020-10-01 |
description |
Expansion of the chemical diversity of glycopeptide antibiotics (GPAs) to deal with the emergence and spread of GPA resistance is challenging. Here, the authors report a GPA synthetic biology platform in Streptomyces coelicolor for Type IV–V glycopeptide antibiotic production and discovery. |
url |
https://doi.org/10.1038/s41467-020-19138-5 |
work_keys_str_mv |
AT minxu gpahexasyntheticbiologyplatformfortypeivvglycopeptideantibioticproductionanddiscovery AT wenliangwang gpahexasyntheticbiologyplatformfortypeivvglycopeptideantibioticproductionanddiscovery AT nicholaswaglechner gpahexasyntheticbiologyplatformfortypeivvglycopeptideantibioticproductionanddiscovery AT elizabethjculp gpahexasyntheticbiologyplatformfortypeivvglycopeptideantibioticproductionanddiscovery AT allisonkguitor gpahexasyntheticbiologyplatformfortypeivvglycopeptideantibioticproductionanddiscovery AT gerarddwright gpahexasyntheticbiologyplatformfortypeivvglycopeptideantibioticproductionanddiscovery |
_version_ |
1714597348871503872 |