Formulation of sublingual promethazine hydrochloride tablets for rapid relief of motion sickness

The delivery of antihistaminic agents via the oral route is problematic, especially for elderly patients. This study aimed to develop a sublingual formulation of promethazine hydrochloride by direct compression, and to mask its intensely bitter taste. Promethazine hydrochloride (PMZ) sublingual tabl...

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Bibliographic Details
Main Authors: Hamad S Alyami, Mohamed A. Ibrahim, Mohammad H. Alyami, Eman Z Dahmash, Osaid T. Almeanazel, Thamer S Algahtani, Fars Alanazi, Doaa H. Alshora
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Saudi Pharmaceutical Journal
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016421000682