Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid

Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid

Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the AlaRS editing system rejects Aze.

Bibliographic Details
Main Authors: Youngzee Song, Huihao Zhou, My-Nuong Vo, Yi Shi, Mir Hussain Nawaz, Oscar Vargas-Rodriguez, Jolene K. Diedrich, John R. Yates, Shuji Kishi, Karin Musier-Forsyth, Paul Schimmel
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02201-z

Internet

https://doi.org/10.1038/s41467-017-02201-z

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