Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the AlaRS editing system rejects Aze.
Bibliographic Details
Main Authors: |
Youngzee Song,
Huihao Zhou,
My-Nuong Vo,
Yi Shi,
Mir Hussain Nawaz,
Oscar Vargas-Rodriguez,
Jolene K. Diedrich,
John R. Yates,
Shuji Kishi,
Karin Musier-Forsyth,
Paul Schimmel |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2017-12-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-017-02201-z
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