Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid

Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the AlaRS editing system rejects Aze.

Bibliographic Details
Main Authors:	Youngzee Song, Huihao Zhou, My-Nuong Vo, Yi Shi, Mir Hussain Nawaz, Oscar Vargas-Rodriguez, Jolene K. Diedrich, John R. Yates, Shuji Kishi, Karin Musier-Forsyth, Paul Schimmel
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02201-z

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spelling	doaj-ab6942f80cab4c61b84fff08d09c316d2021-01-31T12:27:37ZengNature Publishing GroupNature Communications2041-17232017-12-01811810.1038/s41467-017-02201-zDouble mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acidYoungzee Song0Huihao Zhou1My-Nuong Vo2Yi Shi3Mir Hussain Nawaz4Oscar Vargas-Rodriguez5Jolene K. Diedrich6John R. Yates7Shuji Kishi8Karin Musier-Forsyth9Paul Schimmel10The Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research InstituteThe Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research InstituteThe Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research InstituteThe Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research InstituteThe Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research InstituteDepartment of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State UniversityDepartment of Molecular Medicine, The Scripps Research InstituteDepartment of Molecular Medicine, The Scripps Research InstituteThe Scripps Laboratories for tRNA Synthetase Research and Department of Molecular Medicine, The Scripps Research InstituteDepartment of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State UniversityThe Scripps Laboratories for tRNA Synthetase Research and the Department of Molecular Medicine, The Skaggs Institute for Chemical Biology, The Scripps Research InstituteNon-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the AlaRS editing system rejects Aze.https://doi.org/10.1038/s41467-017-02201-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Youngzee Song Huihao Zhou My-Nuong Vo Yi Shi Mir Hussain Nawaz Oscar Vargas-Rodriguez Jolene K. Diedrich John R. Yates Shuji Kishi Karin Musier-Forsyth Paul Schimmel
spellingShingle	Youngzee Song Huihao Zhou My-Nuong Vo Yi Shi Mir Hussain Nawaz Oscar Vargas-Rodriguez Jolene K. Diedrich John R. Yates Shuji Kishi Karin Musier-Forsyth Paul Schimmel Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid Nature Communications
author_facet	Youngzee Song Huihao Zhou My-Nuong Vo Yi Shi Mir Hussain Nawaz Oscar Vargas-Rodriguez Jolene K. Diedrich John R. Yates Shuji Kishi Karin Musier-Forsyth Paul Schimmel
author_sort	Youngzee Song
title	Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
title_short	Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
title_full	Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
title_fullStr	Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
title_full_unstemmed	Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
title_sort	double mimicry evades trna synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-12-01
description	Non-proteinogenic (np) amino acids in the food chain present challenges for the human translation machinery. Here the authors show that, while AlaRS and ProRS activate toxic np azetidine-2-carboxylic acid (Aze) present in sugar beets and lilies, only the AlaRS editing system rejects Aze.
url	https://doi.org/10.1038/s41467-017-02201-z
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Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid

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