αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish

αM-Conotoxin MIIIJ Blocks Nicotinic Acetylcholine Receptors at Neuromuscular Junctions of Frog and Fish

We report the discovery and functional characterization of &#945;M-Conotoxin MIIIJ, a peptide from the venom of the fish-hunting cone snail <i>Conus magus</i>. Injections of &#945;M-MIIIJ induced paralysis in goldfish (<i>Carassius auratus</i>) but not mice. Intracell...

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Bibliographic Details
Main Authors: Matthew J. Rybin, Henrik O’Brien, Iris Bea L. Ramiro, Layla Azam, J. Michael McIntosh, Baldomero M. Olivera, Helena Safavi-Hemami, Doju Yoshikami
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Toxins
Subjects:
venom
conotoxin
nicotinic acetylcholine receptor
neuromuscular junction
Online Access:https://www.mdpi.com/2072-6651/12/3/197

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https://www.mdpi.com/2072-6651/12/3/197

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