ShcD Binds DOCK4, Promotes Ameboid Motility and Metastasis Dissemination, Predicting Poor Prognosis in Melanoma

ShcD Binds DOCK4, Promotes Ameboid Motility and Metastasis Dissemination, Predicting Poor Prognosis in Melanoma

Metastases are the primary cause of cancer-related deaths. The underlying molecular and biological mechanisms remain, however, elusive, thus preventing the design of specific therapies. In melanomas, the metastatic process is influenced by the acquisition of metastasis-associated mutational and epig...

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Bibliographic Details
Main Authors: Ewa Aladowicz, Letizia Granieri, Federica Marocchi, Simona Punzi, Giuseppina Giardina, Pier Francesco Ferrucci, Giovanni Mazzarol, Maria Capra, Giuseppe Viale, Stefano Confalonieri, Sara Gandini, Fiorenza Lotti, Luisa Lanfrancone
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
melanoma metastasis
ShcD adaptor protein
amoeboid motility
Rac1
DOCK4
melanoma PDX
Online Access:https://www.mdpi.com/2072-6694/12/11/3366

Internet

https://www.mdpi.com/2072-6694/12/11/3366

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