The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue

The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue

Macrophages are highly versatile cells, which acquire, depending on their microenvironment, pro- (M1-like), or antiinflammatory (M2-like) phenotypes. Here, we studied the role of the G-protein coupled receptor G2A (GPR132), in chemotactic migration and polarization of macrophages, using the zymosan-...

Full description

Bibliographic Details
Main Authors: Katharina Kern, Stephan M. G. Schäfer, Jennifer Cohnen, Sandra Pierre, Tabea Osthues, Neda Tarighi, Stefan Hohmann, Nerea Ferreiros, Bernhard Brüne, Andreas Weigert, Gerd Geisslinger, Marco Sisignano, Klaus Scholich
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
G2A
GPCR
macrophage
polarization
migration
acute inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02261/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02261/full

Similar Items