Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis

Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis

Caspase-8 or cellular FLICE-like inhibitor protein (cFLIP) deficiency leads to embryonic lethality in mice due to defects in endothelial tissues. Caspase-8−/− and receptor-interacting protein kinase-3 (RIPK3)−/−, but not cFLIP−/− and RIPK3−/−, double-knockout animals develop normally, indicating th...

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Bibliographic Details
Main Authors: Ricardo Weinlich, Andrew Oberst, Christopher P. Dillon, Laura J. Janke, Sandra Milasta, John R. Lukens, Diego A. Rodriguez, Prajwal Gurung, Chandra Savage, Thirumala D. Kanneganti, Douglas R. Green
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713005056

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http://www.sciencedirect.com/science/article/pii/S2211124713005056

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