An Advanced Human Intestinal Coculture Model Reveals Compartmentalized Host and Pathogen Strategies during Salmonella Infection

Infection research routinely employs in vitro cell cultures or in vivo mouse models as surrogates of human hosts. Differences between murine and human immunity and the low level of complexity of traditional cell cultures, however, highlight the demand for alternative models that combine the in vivo-...

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Bibliographic Details
Main Authors: Leon N. Schulte, Matthias Schweinlin, Alexander J. Westermann, Harshavardhan Janga, Sara C. Santos, Silke Appenzeller, Heike Walles, Jörg Vogel, Marco Metzger
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
Online Access:https://doi.org/10.1128/mBio.03348-19