ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice.

ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice.

KLF3 is a Krüppel family zinc finger transcription factor with widespread tissue expression and no previously known role in heart development. In a screen for dominant mutations affecting cardiovascular function in N-ethyl-N-nitrosourea (ENU) mutagenized mice, we identified a missense mutation in th...

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Bibliographic Details
Main Authors: Lois Kelsey, Ann M Flenniken, Dawei Qu, Alister P W Funnell, Richard Pearson, Yu-Qing Zhou, Irina Voronina, Zorana Berberovic, Geoffrey Wood, Susan Newbigging, Edward S Weiss, Michael Wong, Ivan Quach, S Y Sandy Yeh, Ashish R Deshwar, Ian C Scott, Colin McKerlie, Mark Henkelman, Peter Backx, Jeremy Simpson, Lucy Osborne, Janet Rossant, Merlin Crossley, Benoit Bruneau, S Lee Adamson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3708807?pdf=render

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http://europepmc.org/articles/PMC3708807?pdf=render

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