Combination Therapy with Disulfiram, Copper, and Doxorubicin for Osteosarcoma: In Vitro Support for a Novel Drug Repurposing Strategy

Although many cancer cells have significantly higher copper concentrations compared with normal cells and tissues, the role of copper in cancer biology and metastatic disease remains poorly understood. Here, we study the importance of copper in osteosarcoma, which frequently metastasizes to the lung...

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Bibliographic Details
Main Authors: Jonathan B. Mandell, Feiqi Lu, Matthew Fisch, Jan H. Beumer, Jianxia Guo, Rebecca J. Watters, Kurt R. Weiss
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Sarcoma
Online Access:http://dx.doi.org/10.1155/2019/1320201