Zoledronic acid boosts γδ T-cell activity in children receiving αβ+ T and CD19+ cell-depleted grafts from an HLA-haplo-identical donor

Zoledronic acid boosts γδ T-cell activity in children receiving αβ+ T and CD19+ cell-depleted grafts from an HLA-haplo-identical donor

We demonstrated that γδ T cells of patients given HLA-haploidentical HSCT after removal of αβ+ T cells and CD19+ B cells are endowed with the capacity of killing leukemia cells after ex vivo treatment with zoledronic acid (ZOL). Thus, we tested the hypothesis that infusion of ZOL in patients receivi...

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Bibliographic Details
Main Authors: A. Bertaina, A. Zorzoli, A. Petretto, G. Barbarito, E. Inglese, P. Merli, C. Lavarello, L. P. Brescia, B. De Angelis, G. Tripodi, L. Moretta, F. Locatelli, I. Airoldi
Format: Article
Language:English
Published: Taylor & Francis Group 2017-02-01
Series:OncoImmunology
Subjects:
γδ t cells
haematopoietic stem cell transplantation
leukemic patients
proteomic
zoledronic acid
Online Access:http://dx.doi.org/10.1080/2162402X.2016.1216291

Internet

http://dx.doi.org/10.1080/2162402X.2016.1216291

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